Flexible pumping chamber

ABSTRACT

The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to a pumping chamber for such an inhalation device. A pumping unit for an inhalation device for medically active liquids for generation of an aerosol comprises a tubular member ( 1 ), a check valve ( 2 ), and a counter piece, said counter piece being configured to receive at least a downstream segment of said tubular member ( 1 ) and having an interior volume, wherein upstream of said tubular member ( 1 ), a reservoir ( 4 ) can be fluidically connected with said tubular member ( 1 ), and downstream of said counter piece, a nozzle unit ( 6 ) can be fluidically connected with said counter piece, and wherein the tubular member ( 1 ) comprises an upstream section, a downstream section, and the check valve ( 2 ) which is positioned between the upstream section and the downstream section, such that a pumping chamber with a pumping chamber volume is defined which comprises the volume of the downstream section of the tubular member ( 1 ) and said interior volume of the counter piece, and wherein tubular member ( 1 ) and the counter piece can move relatively to one another, such that the pumping chamber volume is variable. The tubular member ( 1 ) comprises at least two mechanically distinct parts ( 1 A,  1 B), wherein a first part ( 1 A) provides said upstream section, and a second part ( 1 B) provides said downstream section, and the first part ( 1 A) and the second part ( 1 B) are connected to each other such as to form an interface section ( 1 C) serving as a valve chamber ( 2 B) for the valve ( 2 ).

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a United States National Stage Application filedunder 35 U.S.C. § 371 claiming priority to and the benefit of PCTApplication No. PCT/EP2018/086833, filed on Dec. 22, 2018, which claimspriority to and the benefit of European Application No. 17210398.8,filed on Dec. 22, 2017, and U.S. Provisional Application Ser. No.62/610,081, filed on Dec. 22, 2017, all of which are incorporated hereinby reference in their entireties.

FIELD OF THE INVENTION

The invention relates to the field of inhalation devices for liquids. Inparticular, the invention relates to a pumping chamber for such aninhalation device.

BACKGROUND OF THE INVENTION

Nebulizers or other aerosol generators for liquids are known from theart since a long time ago. Amongst others, such devices are used inmedical science and therapy. There, they serve as inhalation devices forthe application of active ingredients in the form of aerosols, i.e.small liquid droplets embedded in a gas. Such an inhalation device isknown e.g. from document EP 0 627 230 B1. Essential components of thisinhalation device are a reservoir in which the liquid that is to beaerosolized is contained; a pumping unit for generation of a pressurebeing sufficiently high for nebulizing; as well as an atomizing devicein the form of a nozzle.

Typically, the inhalation device comprises also a pipe which isfluidically connected with its first, upstream end to said reservoir,and with its second, downstream end to said pumping unit. A valve, e.g.a ball valve, which is contained in the pipe ensures that the flow ofliquid can only occur in the desired direction, i.e. from the reservoirto the pumping unit and the nozzle.

The so called pumping chamber is the volume where the liquid iscollected and pressurized for emission through the nozzle. The volume ofthe pumping chamber consists of the pipe's interior volume downstreamthe valve, and the volume of a pumping unit's opening into which thepipe can be inserted during pumping action.

For pumping, and therefore, pressure generation, the pipe is firstlypulled out of the pumping device, such that the overall volume of thepumping chamber increases. The resulting negative pressure inside thechamber leads to the sucking in of liquid from the reservoir through thevalve into the pumping chamber. When the chamber has reached its maximumvolume, the motion can now be reversed. The valve blocks any back flowof liquid into the reservoir, and therefore, a positive pressure buildsup inside the pumping chamber, since the nozzle as the only outlet has arelatively high fluidic resistance. The liquid is forced out of thedownstream end of the pumping device, into the nebulizing structure ofthe nozzle. Once the chamber has reached its minimum volume, an entiredose is delivered. Now, refilling of the chamber can start again. It isclear that by adjusting the travel length and diameter of the pipe, thedosing volume of liquid can be adjusted.

In known devices, the pipe is constructed as a hollow tube made of metalhaving very precise dimensions. Such precision is necessary sinceotherwise, sealing problems might occur. Further, the ball valve islocated inside said tube at a predefined longitudinal position close toa downstream end section of the tube. It is kept in place by a preciselyformed wall structure that allows for a certain longitudinal travelwithin the tube, without letting the ball leaving said end section(cage).

The manufacture of the tube with the necessary precision is costly.Further, if the dosing volume must be adjusted, or if a change of e.g.viscosity of the liquid makes an adjustment of flow resistance, andthus, of the diameter of the tube, necessary, such adjustment is alsoboth a complex and costly measure.

OBJECT OF THE INVENTION

The object of the invention is the provision of a device that avoids thedrawbacks of the known art.

The invention reduces the cost of the pumping unit. Further, theinvention facilitates the adjustment of the fluidic parameters of thepumping unit with respect to pumping volume or to the fluidic parametersof the liquid.

DESCRIPTION OF THE INVENTION

The object is solved by a device according to claim 1. Advantageousembodiments are described in the dependent claims, the subsequentdescription, as well as the accompanying figures.

The invention relates to a pumping unit for an inhalation device formedically active liquids for generation of an aerosol. Preferably, theinhalation device is a soft mist inhaler having a pumping unit designedfor a high working pressure of e.g. 100 bar or more. The pumping unitcomprises a tubular member, a check valve, and a counter piece. Thecounter piece is configured to receive at least a downstream segment ofsaid tubular member. This member can e.g. be a pipe, a hose or the like.Preferably, it is made of a substantially rigid material. The counterpiece has an interior volume which is configured to receive liquid.

Upstream of said tubular member, a reservoir can be fluidicallyconnected with said member, and downstream of said counter piece, anozzle unit can be (directly or indirectly) fluidically connected. Inorder to ensure unidirectional flow of the liquid, a check valve ispresent which is positioned between an upstream section and a downstreamsection. A pumping chamber with a pumping chamber volume is definedwhich comprises the volume of the downstream section of the tubularmember, starting at the valve, and optionally the interior volume of thecounter piece, at least up to the position of a further optional valveaccommodated in the counter piece. If the upstream end of the counterpiece is inserted in the downstream segment of the tubular member, andif the optional (further) valve is positioned at the very upstream endof the counter piece, the interior volume of the counter piece willobviously not contribute to the pumping chamber volume.

On the other hand, it is also clear that the volume of the walls of thedownstream section of the tubular member, if the same is contained in anopening of the counter piece, must be subtracted from the volume of thepumping chamber.

Tubular member and counter piece can move relatively to one another,such that the pumping chamber volume is variable. This pumping principleis a common principle, and can effectively be used for generatingsufficiently high pressures within the pumping chamber when the tubularmember is moved further towards the counter piece, reducing the volumeavailable for the liquid.

According to the invention, the tubular member comprises at least twomechanically distinct parts (and not only sections of one integralpart). This means that prior to a first operation, the tubular membermust be assembled from (at least) two separate parts. The first partprovides said upstream section, and the second part provides saiddownstream section. Further, the first part and the second part areconnected to each other such as to form an interface section serving asa valve chamber for the aforementioned check valve.

As will be shown in more detail further down, the design of the tubularmember in two distinct parts with the valve chamber at the end of thefirst, or at the beginning of the second part, has a number ofadvantages. In short, the construction becomes more simple, and can becarried out with less precision. Moreover, the design makes the assemblyof the pumping unit easier.

In particular, only the second part which comes in contact with thecounter piece must be of higher precision, whereas the first part whichcontacts the reservoir can be of a lower precision. Further, since thesection which houses the valve, i.e. the valve chamber, is easilyaccessible, it is easier to manufacture that region with sufficientlyhigh precision in order to obtain a well working check valve. Also,installation of the valve becomes much easier. Further on, the inventionallows for more flexibility regarding the design and size of the valvechamber. From assembling, it is sufficient to press both parts togetherafter inserting moveable parts of the valve. Also, if the fluidiccharacteristics of the pumping unit must be adjusted, only the secondpart must be exchanged, whereas the first part and the valve can be leftunchanged.

According to a preferred embodiment, the counter piece comprises a riserpipe which extends towards the second part of the tubular member andwhich is at least partially insertable into the second part of thetubular member. This means that a hollow, pipe-like member is presentwhich has an outer diameter that matches the inner diameter of thesecond part of the tubular member. Thus, the latter can slide onto andalong the first until motion is blocked e.g. by the valve reaching theupstream end of the riser pipe, or the downstream end of the tubularmember reaching the downstream end of the counter piece.

In another embodiment, the counter piece comprises an opening, saidopening being configured to receive at least part of the downstreamsection of said tubular member. This means that the tubular member canpartially “dive” into the opening, the inner diameter of which matchingthe outer diameter of the second part of the tubular member.

In both cases, the resulting pumping chamber volume will decrease whenthe tubular member is further approaching the counter piece, andvice-versa. It is noted that also a combination of both embodiments ispossible.

According to one embodiment, the outside diameter of both parts (firstand second part) is substantially identical. This means that the outsideof the entire tubular member has substantially the same size. Such aconstruction allows for a very long travel distance of the tubularmember into the opening or over the riser pipe, respectively, sincethere is no obstacle restraining the motion of the tubular member.Further, only one type of tubes or pipes must be held available formanufacture.

In another embodiment, the outside diameters of both parts differ fromone another. As will be shown, a larger diameter of the section whichhouses the valve chamber allows for greater flexibility with regard tothe design of said chamber and valve. Also, since the pressure in thefirst part is significantly lower than in the second part (only thesecond part belongs to the pumping chamber), the first part mustwithstand lower forces and can therefore have e.g. a thinner wall thatthe second part.

In another embodiment, the valve chamber has a lateral wall, and asection of that part which forms or houses the lateral wall of the valvechamber has an increased diameter with respect to (i) the rest of thispart, or (ii) the other part. In both cases, a larger space for theinterface section, and thus, more space for the valve is provided. Atleast, the internal diameter is increased, but preferably, the externaldiameter is increased as well in order not to weaken the respectivewalls.

In case (i), the part which houses that valve chamber has a locallyenlarged diameter. This allows for providing a larger (wider) valvechamber.

In case (ii), the entire part (first or second part) has a largerdiameter than the other part. In this case as well, more space for thevalve chamber is available, and a part of substantially identicaldiameter can be easier to manufacture than a part which has only localsections of a wider diameter. However, on the other hand, a constructionaccording to (i) uses less space which can be crucial in someapplications.

In other embodiments, the inner diameter of the valve chamber can bedecreased. In certain applications, a smaller and therefore fastermoveable part can be advantageous.

In one embodiment, the part which does not form or comprise the lateralwall of the valve chamber has at its upstream end a structure forholding back a moveable part of the valve. Such a structure has the taskof “closing” the valve chamber such that e.g. the ball (of a ball checkvalve) stays inside the valve chamber. This is achieved in providing astructure that has a clear diameter which is smaller than the diameterof the ball. Of course, other valve types are possible as well, such asflap valves and the like. However, also in these cases, the valvechamber can be closed by a comparable structure that allows motion ofthe moveable part of the valve, but ensures that said part is notleaving the valve chamber.

In one embodiment, said structure for retaining the moveable part of thevalve within the valve chamber is provided by a reduced interiordiameter of said (first or second) part. That means that the part whichdoes not provide the valve chamber has an at least partially reducedinterior diameter which is smaller than the diameter of the ball (incase of a ball valve). Thus, the ball cannot enter the interior of saidpart.

In another embodiment, said structure is provided by a surface insidesaid part with at least two through holes. In other words, the partprovides a sieve like structure which closes the valve chamber for themoveable part, but which lets liquid pass.

The advantage of both embodiments is that, due to the two part design,both described structures can be manufactured rather easily. Since thestructure is arranged at the respective end of the first, or thebeginning of the second part, it is well accessible, and thus,machinable.

In one of the preferred embodiments, the valve chamber is provided bythe second part. By locating the valve chamber in the second part, thesubsequent advantages can be achieved. In this context, the part whichprovides the lateral wall or which contains most of the valve componentsis considered as the part providing the valve chamber.

Firstly, in such a case, the first and the second part canadvantageously be made of different materials. Although this is possiblein other cases as well, in the case when the valve chamber is providedby the second part, the first part can be made of a weaker material thanthe second part, because only the second part is exposed to highpressures. The first part does not hold any high pressure sections,since only the second part houses sections downstream the moveable partof the valve, and only these sections are exposed to said highpressures.

As a result, costly material can be saved, reducing the cost of thepumping unit. Also, processing of weaker materials is usually easier andquicker, again resulting in a reduction of costs.

Secondly, to the first part of the tubular member, easily more than onereservoir can be fluidically connected, such that mixing of thedifferent liquids in the valve chamber can occur. In other words, whenthe valve chamber is not provided by the first part, in turn, said partprovides more design freedom with respect to the “inlets” which connectthe valve chamber via said first part to one or even more reservoirs. A“Y” shaped downstream end of the first part can be provided to connectto two reservoirs, and as a result, the valve chamber serves at the sametime as a mixing chamber for these liquids. Due to the turbulences towhich the liquids are exposed when entering, passing and leaving thevalve chamber, it serves as an ideal (pre-)mixing chamber.

It is of course also possible to provide more than one fluidicconnection to the valve chamber when the latter is provided in the firstpart. However, the aforementioned embodiment is preferred, since theseparation of functions leads to a more simple and thus less costlyconstruction.

The invention relates also to an inhalation device for medically activeliquids for generation of an aerosol, the device comprising a pumpingunit according to the above description. In order to avoid repetitions,reference is made to said description. An inhalation device, comprisingsaid pumping unit, provides a number of advantages; in particular, itcan be manufactured at reduced costs and it can be more easily beadapted to varying fluidic properties of different liquids.

Further, the invention relates to a tubular member for a pumping unitfor an inhalation device for medically active liquids for generation ofan aerosol; the tubular member is defined as described herein-above inthe context of the disclosure of the pumping unit comprising suchtubular member. Such a tubular member is easier to manufacture thanpreviously known tubular members that have a similar functionality.Moreover, the tubular member according to the present invention providesgreater flexibility with regard to adaptation for a broad range offluidic parameters, doses, and necessary space.

DESCRIPTION OF FIGURES

FIG. 1 shows a schematic view of some components of an inhalationdevice.

FIG. 2 shows one embodiment of a tube according to the invention in across sectional view.

FIG. 3 shows a detail of the view of the embodiment of FIG. 2 .

FIG. 4 shows a top view of the embodiment of FIG. 2 .

In FIG. 1 , a schematic cut view of an inhalation device is shown. Thefigure shows the general arrangement of a pumping unit in an inhalationdevice, but without showing all features of the invention.

The inhalation device comprises a housing, inside this housing areservoir 4 for storing a liquid F, and a pumping unit with a pumpingchamber for generation of a pressure inside said pumping chamber. Thepumping chamber is fluidically connected with the reservoir 4 via atubular member 1. The device further comprises a riser pipe 5 which canbe received with at least one reservoir-facing, interior end 5A in saidpumping chamber, and a nozzle 6 which is connected liquid-tight to anexterior end 5B of the riser pipe 5. The pumping chamber volume(interior volume of the pumping chamber) is changeable by means oflinear relative motion of the riser pipe 5 to the tubular member 1.Further, at an downstream end of tubular member 1, a valve 2 is presentin order to keep liquid F from flowing contrary to the desired flowdirection, i.e. towards nozzle 6. Another, optional valve 8 is locatedat the upstream end of riser pipe 5 in order to keep liquid from flowingback from nozzle 6 into the pumping chamber.

Further, a means for the storage of potential energy 7 is provided,which can be manually loaded, wherein the stored energy is releasable tosaid pumping unit when released by activation of a release means (notshown).

In this embodiment, the tubular member 1 can be regarded as comprising afirst part 1A which provides, at its upstream end, the valve chamber forvalve 2, and which further comprises a second part 1B, wherein riserpipe 5, serving as a counter piece, is least partially insertable intosaid second part 1B. In this embodiment, the diameter of first part 1Aand second part 1B are not identical. FIG. 1 does not show that thefirst part 1A and the second part 1B form an interface section servingas a valve chamber for the valve 2.

In FIG. 2 , one preferred embodiment of a tubular member according tothe invention is shown in a cross sectional view. FIG. 3 shows a moredetailed view.

In said embodiment, the tubular member 1 which consists of a first part1A and a second part 1B has, along its extension, an substantiallyidentical diameter, since D1 is approximately equal to D2. Not shown arethe reservoir 4 and the nozzle unit 6 to which the first and the secondpart can respectively be fluidically connected.

In the depicted embodiment, the first part 1A is configured to be indirect fluidic contact with said reservoir 4. In a not depictedembodiment, the first part 1A is configured to be connected to a furthertube or flexible hose, and said further tube or hose can then be indirect or indirect fluidic connection with the reservoir 4. In such anembodiment, the first part 1A servers rather as an adapter part.

In analogy, the same can apply to the second part 1B which can alsoserve as an adapter part for a further tube for contacting the body ofthe pumping unit (hatched component in FIG. 1 around riser pipe 5). Atthe interface section 1C, a check valve 2 is present. In the depictedembodiment, this is a ball valve with a ball 2A located inside a valvechamber 2B.

In the depicted embodiment, the interface section 1C is part of thefirst part 1A. In a not depicted embodiment, the interface section 1C ispart of the second part 1B.

The flow direction of the liquid (not shown) is from the bottom to thetop in both FIGS. 2 and 3 . Valve 2 which is a check valve ensures thatno liquid can flow in the opposite direction.

The part which does not comprise the valve chamber 1C, which is part 1Bin the depicted embodiment, has at its upstream end (in the picture, thelower end) a structure 3 for holding back the moveable part (ball 2A) ofvalve 2. Structure 3 consists of a surface with two through holes, eachhaving an inner diameter which is significantly smaller than thediameter of ball 2A. Thus, ball 2A cannot leave valve chamber 2B indirection of the liquid flow (upwards in the picture). At the same time,liquid can pass ball 2A and flow through said holes. In the oppositedirection, the valve seat 2C is present, which also blocks furthermovement of ball 2A, and which additionally seals against said backflow.

Both parts 1A and 1B can be pressed together in order to provide asufficiently tight seal. While part 1B should be manufactured withhigher precision since it slides into an out of the opening in the bodyof the pumping unit (not shown), the lower part 1A can be fabricatedwith less precision. Furthermore, the material of the first part 1A canbe of a lower strength than the material of second part 1B since mainly,only part 1B is exposed to high pressures.

In FIG. 4 , the top view onto second part 1B is depicted, and the twothrough holes of structure 3 can be seen from the outside.

LIST OF REFERENCES

1 tubular member

1A first part

1B second part

1C interface section

2 valve, check valve

2A ball, moveable part

2B valve chamber

2C valve seat

3 structure

4 reservoir

5 riser pipe

5A interior end

5B exterior end

6 nozzle, nozzle unit

7 means for the storage of potential energy

8 valve

D1 diameter of first part

D2 diameter of second part

The invention claimed is:
 1. Pumping unit for an inhalation device formedically active liquids for generation of an aerosol, wherein thepumping unit comprises a tubular member, a check valve, and a counterpiece, said counter piece being configured to receive at least adownstream segment of said tubular member and having an interior volume,wherein upstream of said tubular member, a reservoir is directly orindirectly fluidically connected with said tubular member, anddownstream of said counter piece, a nozzle unit is directly orindirectly fluidically connected with said counter piece, and whereinthe tubular member comprises an upstream section, a downstream section,and the check valve which is positioned between the upstream section andthe downstream section, such that a pumping chamber with a pumpingchamber volume is defined which comprises the volume of the downstreamsection of the tubular member and optionally said interior volume of thecounter piece, and wherein tubular member and the counter piece moverelatively to one another, such that the pumping chamber volume isvariable, characterized in that the tubular member comprises at leasttwo mechanically distinct parts, wherein a first part provides saidupstream section, and a second part provides said downstream section,and wherein the first part and the second part are connected to eachother such as to form an interface section serving as a valve chamberfor the valve, wherein the counter piece comprises a riser pipe whichextends towards the second part of the tubular member and which is atleast partially insertable into the second part of the tubular member;and wherein the riser pipe extends through a furthest downstream end ofthe second part of the tubular member.
 2. Pumping unit according toclaim 1, wherein the outside diameter of the first and the second partis substantially identical.
 3. Pumping unit according to claim 1,wherein the outside diameters of the first and the second part differfrom one another.
 4. Pumping unit according to claim 1, wherein thefirst and the second part are made of different materials.
 5. Pumpingunit according to claim 1, wherein to the first part of the tubularmember, more than one reservoir is directly or indirectly fluidicallyconnected.
 6. Inhalation device for medically active liquids forgeneration of an aerosol, comprising a pumping unit according to claim1.